Passport Health logo
VACCINATIONS|FIND A TRAVEL CLINIC|ADVICE
  • Home
    • About
        • Company History
        • Careers
        • Executive Team
        • Contact Us
        • Customer Feedback
        • FAQ
        • Mission Statement
        • Privacy Policy
        • Blog
    • Close
  • Destination Advice
    • Top Destinations
        • Brazil
        • China
        • Costa Rica
        • India
        • Kenya
        • Peru
        • Philippines
        • South Africa
        • Thailand
        • Vietnam
    • Destination Advice
          • Afghanistan
          • Albania
          • Algeria
          • American Samoa
          • Andorra
          • Angola
          • Anguilla
          • Antarctica
          • Antigua and Barbuda
          • Argentina
          • Armenia
          • Aruba
          • Australia
          • Austria
          • Azerbaijan
          • Azores
          • Bahamas
          • Bahrain
          • Balearics
          • Bangladesh
          • Barbados
          • Belarus
          • Belgium
          • Belize
          • Benin
          • Bermuda
          • Bhutan
          • Bolivia
          • Bonaire
          • Bora Bora
          • Bosnia
          • Botswana
          • Brazil
          • British Virgin Islands
          • Brunei
          • Bulgaria
          • Burkina Faso
          • Burma
          • Burundi
          • Cambodia
          • Cameroon
          • Canada
          • Canary Islands
          • Cape Verde
          • Cayman Islands
          • Central African Republic
          • Chad
          • Chile
          • China
          • Christmas Island
          • Cocos (Keeling) Islands
          • Colombia
          • Comoros
          • Cook Islands
          • Costa Rica
          • Cote d'Ivoire
          • Croatia
          • Cuba
          • Curacao
          • Cyprus
          • Czechia
          • Democratic Republic of the Congo
          • Denmark
          • Djibouti
          • Dominica
          • Dominican Republic
          • East Timor
          • Easter Island
          • Ecuador
          • Egypt
          • El Salvador
          • Equatorial Guinea
          • Eritrea
          • Estonia
          • Ethiopia
          • Falkland Islands
          • Faroe Islands
          • Fiji
          • Finland
          • France
          • French Guiana
          • French Polynesia
          • Gabon
          • Gambia
          • Georgia
          • Germany
          • Ghana
          • Gibraltar
          • Greece
          • Greenland
          • Grenada
          • Guadeloupe
          • Guam
          • Guatemala
          • Guinea-Bissau
          • Guinea
          • Guyana
          • Haiti
          • Hawaii
          • Honduras
          • Hong Kong
          • Hungary
          • Ibiza
          • Iceland
          • India
          • Indonesia
          • Iran
          • Iraq
          • Ireland
          • Israel
          • Italy
          • Jamaica
          • Japan
          • Jordan
          • Kazakhstan
          • Kenya
          • Kiribati
          • Kosovo
          • Kuwait
          • Kyrgyzstan
          • Laos
          • Latvia
          • Lebanon
          • Lesotho
          • Liberia
          • Libya
          • Liechtenstein
          • Lithuania
          • Luxembourg
          • Macau
          • Macedonia
          • Madagascar
          • Madeira Islands
          • Malawi
          • Malaysia
          • Maldives
          • Mali
          • Malta
          • Marshall Islands
          • Martinique
          • Mauritania
          • Mauritius
          • Mayotte
          • Mexico
          • Micronesia
          • Moldova
          • Monaco
          • Mongolia
          • Montenegro
          • Montserrat
          • Morocco
          • Mozambique
          • Namibia
          • Nauru
          • Nepal
          • Netherlands
          • New Caledonia
          • New Zealand
          • Nicaragua
          • Niger
          • Nigeria
          • Niue
          • Norfolk Island
          • North Korea
          • Northern Mariana Islands
          • Norway
          • Oman
          • Pakistan
          • Palau
          • Palestinian Territories
          • Panama
          • Papua New Guinea
          • Paraguay
          • Peru
          • Philippines
          • Pitcairn Islands
          • Poland
          • Portugal
          • Puerto Rico
          • Qatar
          • Republic of the Congo
          • Réunion
          • Romania
          • Russia
          • Rwanda
          • Saba
          • St. Barthelemy
          • Saint Helena
          • St. Kitts and Nevis
          • St. Lucia
          • Saint Martin
          • St. Pierre-et-Miquelon
          • St. Vincent and the Grenadines
          • Samoa
          • San Marino
          • Sao Tome and Principe
          • Saudi Arabia
          • Senegal
          • Serbia
          • Seychelles
          • Sierra Leone
          • Singapore
          • Sint Eustatius
          • Slovakia
          • Slovenia
          • Solomon Islands
          • Somalia
          • South Africa
          • South Georgia and the South Sandwich Islands
          • South Korea
          • South Sudan
          • Spain
          • Sri Lanka
          • Sudan
          • Suriname
          • Swaziland
          • Sweden
          • Switzerland
          • Syria
          • Tahiti
          • Taiwan
          • Tajikistan
          • Tanzania
          • Thailand
          • Togo
          • Tokelau
          • Tonga
          • Trinidad and Tobago
          • Tunisia
          • Turkey
          • Turkmenistan
          • Turks and Caicos Islands
          • Tuvalu
          • U.S. Virgin Islands
          • Uganda
          • Ukraine
          • United Arab Emirates
          • United Kingdom
          • United States
          • Uruguay
          • Uzbekistan
          • Vanuatu
          • Vatican
          • Venezuela
          • Vietnam
          • Wake Island
          • Western Sahara
          • Yemen
          • Zambia
          • Zimbabwe
    • Close
  • Travel Medicine
    • Travel Medical Services
        • Vaccines for Travel
        • Travel Health Consulting
        • Travellers’ Diarrhea Kits
        • Dengue Fever Prevention
        • Malaria Medication
        • Chikungunya Prevention
        • Zika Virus Prevention
        • Ebola Virus
        • Coronavirus
    • Close
  • Vaccinations
    • Key Travel Vaccines
      • Typhoid
      • Yellow Fever
      • Hepatitis A
      • Rabies
      • Japanese Encephalitis
      • Drug Identification Numbers (DIN)
    • Other Travel Vaccines
      • Cholera (Dukoral)
      • Hep A/Typhoid Combo (Vivaxim)
      • Hepatitis B
      • Malaria Information
      • Meningitis
      • Polio
    • Routine Vaccinations
      • Tetanus-Diphtheria-Pertussis
      • Measles – Mumps – Rubella (MMR)
      • Pneumonia
      • Shingles
      • Influenza (The Flu)
    • Close
  • Other Services
    • Additional Services
      • TB Tests
      • Physician Referral Program
    • Close
  • For Employers
    • Corporate Wellness Solutions
      • Travel Medicine & Vaccinations
      • Onsite Flu Clinics
      • Onsite Vaccination Clinics
      • Biometric Screenings
      • Vaccine Credentialing
    • Close
  • Locations
        • Ontario
          Barrie Travel Clinic
          Brampton Travel Clinic
          Carlington - Ottawa Travel Clinic
          Downtown - Ottawa Travel Clinic
          Etobicoke Travel Clinic
          Hamilton Travel Clinic
          Kingston Travel Clinic
          Kitchener Travel Clinic
          London Travel Clinic
          Markham Travel Clinic
          Mississauga Travel Clinic
          North York Travel Clinic
          Oakville Travel Clinic
          Richmond Hill Travel Clinic
          St. Catharines Travel Clinic
          Toronto Travel Clinic
          Whitby Travel Clinic
          Yorkville Travel Clinic
        • Alberta
          Chinook - Calgary Travel Clinic
          Downtown Calgary Travel Clinic
          Downtown Edmonton Travel Clinic
          Southeast Edmonton Travel Clinic
          St. Albert Travel Clinic
        • British Columbia
          Burnaby Travel Clinic
          Downtown Vancouver Travel Clinic
          North Vancouver Travel Clinic
          Richmond Travel Clinic
          Surrey Travel Clinic
        • Quebec
          Clinique Santé-Voyage Centre-Ville Montréal
          Clinique Santé-Voyage Laval
          Clinique Santé-Voyage Ville de Québec
          Clinique Santé-Voyage Westmount
    • Close

What’s the Difference Between Weakened and Dead Vaccines?

December 15, 2018 by Caitlin Hartwyk

A weakened and dead vaccine can offer much different levels of protection.

If you’ve ever done any research into vaccinations, you may have come across the different kind of viruses in those vaccines.

Some vaccines contain a dead or inactive version of the virus they’re protecting against. Other use a weakened or live version of the virus.

But, what’s the difference between weakened and dead vaccines?

What is a Dead Vaccine?

A dead vaccine may also be called an inactivated vaccine. These vaccines contain killed or inactive versions of the pathogen that the vaccine is helping to protect against. These pathogens may have been killed through chemicals or via heat.

Vaccines with a dead virus work because once the dead pathogen reaches the immune system, the immune system reacts. The body knows how to fight the virus, without the danger of getting sick from that vaccine.

Usually, when it comes to dead or inactivated vaccines, booster shots are required. Due to the fact that it is dead, the response from the immune system isn’t as strong as it would be if it were a weakened vaccine.

They also cannot be stored without refrigeration because they are quite fragile.

Some dead vaccines include: polio, cholera, influenza, hepatitis A, and typhoid.

What is a Weakened Vaccine?

A weakened vaccine can also be known as a live or attenuated vaccine. The bacteria in these vaccines is cultured in a laboratory and are a weakened version of the actual bacteria.

These vaccines work because once they are injected, the bacteria expands and grows, causing a response in your immune system. Once this happens, the immune system can start producing antibodies to fight against it. So, when your body experiences the “real” virus, your immune system will have already built up a defense against it.

Attenuated vaccines are stronger than a dead vaccine and only need one or two doses per lifetime. They can also be stored without refrigeration.

Some examples of weakened or live vaccines include: MMR, yellow fever, oral polio vaccination, and the oral typhoid vaccination.

So, What Does All This Mean?

The largest difference between a live and dead vaccine is that a live vaccine elicits a stronger response in your immune system than a dead one. As mentioned above, that means that a live vaccination can last a lifetime. A dead vaccination requires regular booster shots throughout your life.

When being immunized, some worry that the vaccine’s virus can get you sick. There is a small and rare chance that the live bacteria in the weakened vaccine can revert back to its original form and actually cause the disease.

This is an increased risk for individuals with a compromised immune system including individuals with AIDS, patients undergoing chemotherapy, or patients who have had an organ transplant. These individuals should always talk to a doctor before receiving any form of live vaccine.

Again, these instances are rare when it comes to live vaccinations, but you should always be aware.

Dead vaccines are completely safe and pose no risk of causing the actual disease.

Do you have any questions about these vaccines, or any others? Passport Health can help. Call us at to schedule an appointment or book it online today.

Did you know there was such a difference between weakened and dead vaccines? Let us know in the comments, or via Facebook and Twitter.

Written for Passport Health by Kaitlyn Luckow. Kaitlyn is a freelance writer, photographer and English teacher in Milwaukee. She has a passion for capturing and writing other people’s stories. You can find her at sayhellostory.com.

Filed Under: General Posts

About Us

Passport Health's blog provides travelers and travel enthusiasts with a variety of news and features. We focus on bringing the most interesting and relevant stories right to our readers. Topics range from the vaccines needed for a destination to updates on recent outbreaks, travel advice and much more. Feel free to check out some of our most popular posts, linked in the sidebar, or our most recent posts below

Recent Blog Posts

  • How Did the New Omicron Variant Develop? Why Did it Develop So Quickly?
  • When to Get the Twinrix Vaccine Before Traveling Abroad
  • Will There Ever Be a Cure For HPV?
  • The History of AIDS

Blog Archives

  • About Us
  • Clinical Trials
  • Contact Us
  • PIPEDA Policy and Consent Form
  • Privacy Policy
  • Automatic Data Collection Statement
  • Sitemap
Schedule Your Appointment
Questions? Please call or E-mail Us
Connect With Us:
Passport Health Canada on Facebook
Passport Health on Twitter
Passport Health on YouTube
Passport Health on Instagram
Passport Health on Linked In
Passport Health Feed

Passport Health is an Outlier business Passport Health es una empresa que pertenece al grupo Outlier Passport Health est une entreprise du groupe Outlier Copyright © 2023